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Emerging Concepts in Acute Kidney Injury Following Cardiac Surgery

Department of Anesthesiology Duke University Medical Center, Durham, North Carolina

Jordan Hudson, MD

Department of Anesthesiology Duke University Medical Center, Durham, North Carolina

Madhav Swaminathan, MD

Department of Anesthesiology Duke University Medical Center, Durham, North Carolina

Andrew Shaw, MD

Department of Anesthesiology Duke University Medical Center, Durham, North Carolina

Mark Stafford-Smith, MD

Department of Anesthesiology Duke University Medical Center, Durham, North Carolina

Uptal D. Patel, MD

Department of Medicine Duke University Medical Center, Durham, North Carolina, uptal.patel{at}duke.edu

Acute kidney injury (AKI) remains a significant cause of morbidity and mortality following cardiac surgery. Through a more thorough understanding of perioperative genomics and the evolving role of early biomarkers ofAKI, the authors seek to improve meaningful outcomes among cardiac surgery patients. In this review, the focus will be on advances in risk stratification, evolving definitions and improving early diagnosis of AKI, identification of effective individualized therapies, and future directions.

Key Words: acute kidney injury • cardiac surgery • genetic polymorphism • biomarker • risk stratification

This version was published on December 1, 2008

Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 12, No. 4, 320-330 (2008)
DOI: 10.1177/1089253208328582


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