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The Inflammatory Response to Cardiopulmonary Bypass— Should It Be Treated?

Department of Anesthesiology and Pain Management, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX

Proinflammatory cytokines, including tumor necrosis factor (TNF) and the interieukins, are important in the metabolic response to injury or infection. Although the importance of cytokine release during cardiopulmonary bypass (CPB) is not fully appreciated, increasing num bers of publications present evidence that cytokine release during CPB is detrimental. In addition, endoge nous inhibitors of cytokine function, including TNF-sol uble receptor and interleukin 1 receptor antagonist, are released in response to elevated proinflammatory cyto kine levels during and after CPB. The involvement of these endogenous inhibitors in the pathophysiology of proinflammatory cytokine-induced solid organ injury after CPB remains to be defined.

Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 5, No. 3, 229-235 (2001)
DOI: 10.1053/scva.2001.26128


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