Seminars in Cardiothoracic and Vascular Anesthesia

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gramlich, L. A.
Right arrow Articles by Barnes, S. D.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Gramlich, L. A.
Right arrow Articles by Barnes, S. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 5, No. 1, 117-121 (2001)
DOI: 10.1177/108925320100500115

Aprotinin Use in Pediatric Cardiac Surgery

Lisa A. Gramlich

Department of Anesthesiology, Rush-Prebyterian-St ukes Medical Center

Steve D. Barnes

Department of Pediatrics, Rush-Prebyterian-St ukes Medical Center

Aprotinin is a serine protease inhibitor that inhibits kal likrein and plasmin. Aprotinin's plasmin inhibition accounts for its antifibrinolytic and platelet-sparing effects, which are important factors for its homeostatic efficacy. The kallikrein inhibition occurs at higher plasma levels and is the mecha nism accounting for its anti-inflammatory actions. Aprotinin has relatively large acquisition costs, but these costs are offset by potential reductions in transfusions and intensive care costs. This review summarizes the pediatric literature and develops generalized recommendations for the effica cious use of aprotinin.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?