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Journal of the Society for Gynecologic Investigation
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Regulation of Fetal Fibronectin Production in Human Amnion Cells

G. Marc Jackson, MD

Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah: and Adeza Biomedical, Sunnyvale, California; Department of Obstetrics and Gynecology, University of Utah, 50 North Medical Drive, Room 2B200, Salt Lake City, UT 84132

Samuel S. Edwin, BS

Michael W. Varner, MD

David Casal, PhD

Murray D. MItchell, DPhil,DSc

Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah: and Adeza Biomedical, Sunnyvale, California

Objective: We evaluated the role of human annion in the production of fetal fibronectin and assessed the regulation of fetal fibronectin production by inflammatory products and cytokines.

Methods: Human annion cells were grown in culture. At confluence, the cells were incubated with and without lipopolysaccharide, interleukin-1ß, tumor necrosis factor-{alpha}, and interleukin-6. Fetal fibronectin production was measured in the supermatant fluid using an enzyme-linked immunosorbent assay technique.

Results: Unstimulated amnion cells produced fetal fibronectin, and production was increased by lipopolysaccharide, interleukin-1ß, tumor necrosis factor-{alpha}, and interleukin-6.

Conclusion: Human amnion cells in vitro produce fetal fibronectin in substantial quantities. This production is stimulated by inflammatory products and mediators that are considered to be important in the initiation of some cases of preterm labor.

Key Words: Fetal fibronectin • human amnion • preterm labor • inflammation

Journal of the Society for Gynecologic Investigation, Vol. 3, No. 2, 85-88 (1996)
DOI: 10.1177/107155769600300208
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