Seminars in Cardiothoracic and Vascular Anesthesia

 

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Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 3, No. 1, 9-16 (1999)
DOI: 10.1177/108925329900300103

Heparin-Bonded Circuits Decrease Thromboembolic Complications and Improve Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery

Gabriel S. Aldea, MD

Department of Cardiothoracic Surgery, Boston University School of Medicine, Boston Medical Center, Boston, MA

Two prospective, randomized studies were performed to definitively evaluate the safety and efficacy of heparin- bonded circuits in patients undergoing primary coro nary artery bypass graft surgery and to clarify the effect of anticoagulation protocol on clinical and neurologic outcomes. These studies showed that the use of heparin- bonded circuits with lower anticoagulation results in markedly improved clinical outcomes in patients under going primary coronary artery bypass graft surgery with a reduction in both clinical and microscopic throm boembolic risks. The mechanisms by which heparin- bonded circuits affect clinical and neurologic outcomes are explored.


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