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Seminars in Cardiothoracic and Vascular Anesthesia
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*Pulmonary Hypertension
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Pathophysiology of Pulmonary Arterial Hypertension

Suma Jain, MD

Section of Pulmonary/Critical Care Medicine, Ochsner Foundation Clinic, Jefferson

Hector Ventura, MD

Department of Cardiology, Ochsner Foundation Clinic, Jefferson

Ben deBoisblanc, MD

Section of Pulmonary/Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, bdeboi{at}lsuhsc.edu

The mechanisms leading to elevations in precapillary pulmonary vascular resistance are complex and likely involve multiple pathways, but the histopathologic sequelae of these processes are restricted to a few findings, primarily neoangiogenesis, intimal and smooth muscle proliferation, vasoconstriction, and/or in situ thrombosis. Regardless of the etiology of pulmonary hypertension, abnormalities in endothelial function are often observed and likely play a central role in mediating structural changes.

Key Words: pulmonary arterial hypertension • nitric oxide pathway • endothelial disfunction

Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 11, No. 2, 104-109 (2007)
DOI: 10.1177/1089253207301732
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