SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Seminars in Cardiothoracic and Vascular Anesthesia
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Mossad, E. B.
Right arrow Articles by Apostolakis, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Mossad, E. B.
Right arrow Articles by Apostolakis, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Bleeding Following Deep Hypothermia and Circulatory Arrest in Children

Emad B. Mossad, MD

Cleveland Clinic, Departments of Cardiothoracic Anesthesia, Cleveland, Ohio; Pediatric Anesthesia, Cleveland, Ohio; mossade{at}ccf.org

Sandra Machado, MD

Center for Neurological Restoration, Cleveland, Ohio

John Apostolakis, MD

Cleveland Clinic, Departments of Cardiothoracic Anesthesia, Cleveland, Ohio

Deep hypothermic circulatory arrest (DHCA) is a technique of extracorporeal circulation commonly used in children with complex congenital heart defects undergoing surgical repairs. The use of profound cooling (20°C) and complete cessation of circulation allow adequate exposure and correction of these complex lesions, with enhanced cerebral protection. However, the profound physiologic state of DHCA results in significant derangement of the coagulation system and a high incidence of postoperative bleeding. This review examines the impact of DHCA on bleeding and transfusion requirements in children and the pathophysiology of DHCA-induced platelet dysfunction. It also focuses on possible pharmacologic interventions to decrease bleeding following DHCA in children.

Key Words: hypothermia • circulatory arrest • antifibrinolytics • coagulopathy • platelet dysfunction

Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 11, No. 1, 34-46 (2007)
DOI: 10.1177/1089253206297413
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement