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Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 10, No. 4, 346-360 (2006)
DOI: 10.1177/1089253206294400

Inhaled Milrinone: A New Alternative in Cardiac Surgery?

André Y. Denault, MD, FRCPC

Department of Cardiac Anesthesiology, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada, denault{at}videotron.ca

Yoan Lamarche, MD, MSc

Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada

Pierre Couture, MD, FRCPC

Francois Haddad, MD, FRCPC

Medicine (Division of Cardiology), Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada

Jean Lambert, PhD

Biostatistics, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada

Jean-Claude Tardif, MD, FRCPC

Medicine (Division of Cardiology), Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada

Louis P. Perrault, MD, PhD, FRCSC

Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada

The administration of milrinone through inhalation has been studied in only a few animal and human studies. Compared to the intravenous administration, inhaled milrinone has been shown to reduce pulmonary artery pressure without systemic hypotension. Therefore, this approach could represent an alternative to nitric oxide. This current state of knowledge of intravenous and inhaled milrinone is presented and summarized.

Key Words: milrinone • pulmonary artery pressure • nitric oxide • heart failure


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