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Seminars in Cardiothoracic and Vascular Anesthesia
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Genetic Influences on Cerebral Outcome After Cardiac Surgery

Hilary P. Grocott, MD, FRCPC

Duke University Medical Center, Durham, North Carolina, h.grocott{at}duke.edu

Just as the influence of genetic variation on patient outcomes is being discussed in many other areas of medicine, so too are its effects on cerebral outcome after cardiac surgery now being described. Whereas early studies focused on neurocognitive outcome, where the single nucleotide polymorphisms of APOE4 and PLA2 were the first investigated genetic targets, stroke is now being elaborated on with related single and multi-gene single nucleotide polymorphisms having been identified. Our work has established key links between post-cardiac surgery stroke and C-reactive protein (3’UTR 1846C/T) and interleukin-6 (-174 G/C) single nucleotide polymorphisms.

Key Words: genetics • polymorphism • cardiac surgery • outcome • stroke

Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 10, No. 4, 291-296 (2006)
DOI: 10.1177/1089253206294344
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