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Seminars in Cardiothoracic and Vascular Anesthesia
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Free Fatty Acids and Postischemic Myocardial Function

Ger J. van der Vusse, PhD

Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands; vanderVusse{at}fys.unimaas.nl

Marc van Bilsen, PhD

Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands

This review highlights the changes in fatty acid homeostasis in the postischemic heart. The impact of restoration of flow (reperfusion) after an ischemic episode on both structural fatty acids (ie, incorporated in phospholipids, the building blocks of cellular membranes) and fatty acids, serving as energy donors by mitochondrial oxidation, are discussed. Attempts to interfere with cardiac fatty acid homeostasis to prevent loss of cardiac function or to restore cardiac performance after reperfusion is also discussed.

Key Words: heart • reperfusion • fatty acid oxidation

Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 10, No. 3, 231-235 (2006)
DOI: 10.1177/1089253206291319
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