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Seminars in Cardiothoracic and Vascular Anesthesia
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Optimizing Cardiac Fatty Acid and Glucose Metabolism as an Approach to Treating Heart Failure

Gary D. Lopaschuk, PhD

Cardiovascular Research Group, University of Alberta, Edmonton, Alberta T6G 2S2 Canada; gary.lopaschuk{at}ualberta.ca

Despite the recent introduction of new therapeutic approaches to treat heart failure, mortality from heart failure remains high, and patients still frequently experience progression of contractile dysfunction and ongoing left ventricular enlargement. Therefore, new treatments are needed for heart failure that work independently of mechanisms already targeted. Emerging evidence suggests that the failure of the myocardium in heart failure is affected by alterations in the energy substrate metabolism. In particular, there is now evidence that in the failing heart, shifting metabolism away from a preference for fatty acids toward more carbohydrate oxidation can improve contractile function and slow the progression of pump failure.

Key Words: fatty acid oxidation • glucose oxidation • trimetazidine

Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 10, No. 3, 228-230 (2006)
DOI: 10.1177/1089253206291150
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