Seminars in Cardiothoracic and Vascular Anesthesia

 

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Seminars in Cardiothoracic and Vascular Anesthesia, Vol. 1, No. 4, 295-318 (1997)
DOI: 10.1177/108925329700100404

Hypercoagulable States

Peter Robbins, FRCA

Department of Anaesthesia, University College London and Royal Free School of Anaesthesia, London, UK

Mark Forrest, FRCA

Department of Anaesthesia, Charing Cross Hospital and Hammersmith School of Anaesthesia, London, UK

David Royston, MB, FFARCAS

Harefield Hospital, Middlesex, UK

The hypercoagulable states consist of a group of prothrombotic clinical disorders associated with an increased risk for thromboembolic events. The abnormalities lead to inappropriate thrombus formation. After a review of the coagulation process, inherited disorders (including antithrombin-III deficiency, protein CS system deficiencies, disorders of plasmin generation, dysfibrinogenemias, and homocysteinuria) and acquired disorders (including responses to surgery, cancer, drugs, and the antiphospholipid syndrome) are described. Screening and management methods are discussed. Copyright © 1997 by W. B. Saunders Company.


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